"In a TV series, it can be many years [of work]," Venditti explained. "We all love her, but when we went through the rigors 

of the process, we didn't know if she could handle what it would take in terms of physical and mental stamina."

After Venditti and Euphoria creator Sam Levinson determined that the unknown actress was not ready, they found their girl.

"It's so interesting. A polar opposite," Venditti said. "Because here is Zendaya, who has none of Rue's life experiences, who was able to dig into her abilities and access her in such a beautiful way."

Zendaya recently opened up about the process of creating Rue, despite not having gone through the same struggles in real life.

"Rue became a fusion of my experiences, [Euphoria creator Sam Levinson's] experiences, and our collective 

pain-and seeing it through the eyes of an addict," she explained to Variety in June. 

"I think the approach was to try as human as possible, without ever shying away from the devastation and the ugliness that that can create."

When it came time to cast the role of Jules, played by Hunter Schafer, the casting department ran into a different problem.

"I contacted her agent and they originally went through. [The actress] had to be open to any kind of sexual situation," Venditti said. 

"So imagine you weren't really thinking about acting, and someone brings an opportunity with possible nudity."

Euphoria represented Schafer's acting debut after the young woman made a name for herself in the fashion industry.